The lncRNA Toolkit: Databases and In Silico Tools for lncRNA Analysis

LncRNA in lung development 3. LncRNA in lung inflammation 4. LncRNA and cigarette smoke 5. LncRNA and lung cancer 6. LncRNA and pulmonary hypertension 7. LncRNA and lung fibrosis

Long non-coding RNAs (lncRNAs) represent a surprisingly novel field in mammalian transcriptome research. With the development of RNA sequencing technology and computational methods, lncRNAs have been demonstrated to have important roles in biological processes at the epigenetic, transcription and post-transcriptional levels. In addition, the dysregulation of lncRNAs contributes to numerous dise...

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

Long non-coding RNAs (lncRNAs) play key roles in diverse biological processes. Moreover, the development and progression of cancer often involves the combined actions of several lncRNAs. Here we propose a multi-step method for constructing lncRNA-lncRNA functional synergistic networks (LFSNs) through co-regulation of functional modules having three features: common coexpressed genes of lncRNA p...

lncRNA definitions and mechanisms

Introduction Approximately three-quarters of the mammalian genome is transcribed into RNA (1–3); however, only a fraction of this transcription produces mRNA, whose mature nucleotide sequence serves as a template for protein synthesis (3). The function of this nonprotein-coding RNA (or noncoding RNA) is mostly obscure, despite a larger number of noncoding genes than protein-coding genes. Given ...

lncRNA and gene looping

the search for the self in becketts theatre: waiting for godot and endgame

this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...